MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.

@article{Spehalski2017MRE11PT,
  title={MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.},
  author={Elizabeth I. Spehalski and Kayla M Capper and Cheryl J Smith and Mary J. Morgan and Maria Dinkelmann and Jeffrey Buis and J M Sekiguchi and David O. Ferguson},
  journal={Cancer research},
  year={2017},
  volume={77 19},
  pages={
          5327-5338
        }
}
Hypomorphic mutations in the genes encoding the MRE11/RAD50/NBS1 (MRN) DNA repair complex lead to cancer-prone syndromes. MRN binds DNA double-strand breaks, where it functions in repair and triggers cell-cycle checkpoints via activation of the ataxia-telangiectasia mutated kinase. To gain understanding of MRN in cancer, we engineered mice with B lymphocytes lacking MRN, or harboring MRN in which MRE11 lacks nuclease activities. Both forms of MRN deficiency led to hallmarks of cancer, including… CONTINUE READING

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