MRE11–RAD50–NBS1 and ATM function as co-mediators of TRF1 in telomere length control

@article{Wu2007MRE11RAD50NBS1AA,
  title={MRE11–RAD50–NBS1 and ATM function as co-mediators of TRF1 in telomere length control},
  author={Yili Wu and Shujie Xiao and Xu-Dong Zhu},
  journal={Nature Structural &Molecular Biology},
  year={2007},
  volume={14},
  pages={832-840}
}
Human telomeres are associated with ATM and the protein complex consisting of MRE11, RAD50 and NBS1 (MRN), which are central to maintaining genomic stability. Here we show that when targeted to telomeres, wild-type RAD50 downregulates telomeric association of TRF1, a negative regulator of telomere maintenance. TRF1 binding to telomeres is upregulated in cells deficient in NBS1 or under ATM inhibition. The TRF1 association with telomeres induced by ATM inhibition is abrogated in cells lacking… CONTINUE READING

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