MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.

  title={MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family.},
  author={Li F. Chan and Tom R Webb and T T L L Chung and Eirini Meimaridou and Sadani N. Cooray and Leonardo Guasti and J. Paul Chapple and Michaela Egertov{\'a} and Maurice R Elphick and Michael E Cheetham and Louise A Metherell and Adrian J. L. Clark},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={106 15},
The melanocortin receptor (MCR) family consists of 5 G protein-coupled receptors (MC1R-MC5R) with diverse physiologic roles. MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, whereas MC3R and MC4R have an essential role in energy homeostasis. Mutations in MC4R are the single most common cause of monogenic obesity. Investigating the way in which these receptors signal and traffic to the cell membrane is vital in understanding disease processes related to MCR dysfunction… CONTINUE READING
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