MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.

  title={MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.},
  author={Christophe Rochais and Thierry Cresteil and Vittoria Perri and Marie Jouanne and Aur{\'e}lien Lesnard and Sylvain Rault and Patrick Dallemagne},
  journal={Cancer letters},
  volume={331 1},
This work describes the study of the mechanism of action and spectrum of activity of MR22388, a novel anti-cancer agent belonging to the tripentone series. MR22388 is highly cytotoxic (within the nanomolar range) against numerous cancer cell lines and studies of its cytotoxicity mechanisms show that it is a weak inhibitor of the polymerization of tubulin and that it induces apoptosis via the MAP kinase pathways. Further MR22388 is a very strong inhibitor of several kinases including the… CONTINUE READING


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