MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.

@article{Rochais2013MR22388AN,
  title={MR22388, a novel anti-cancer agent with a strong FLT-3 ITD kinase affinity.},
  author={C. Rochais and T. Cresteil and Vittoria Perri and Marie Jouanne and Aur{\'e}lien Lesnard and S. Rault and P. Dallemagne},
  journal={Cancer letters},
  year={2013},
  volume={331 1},
  pages={
          92-8
        }
}
  • C. Rochais, T. Cresteil, +4 authors P. Dallemagne
  • Published 2013
  • Biology, Medicine
  • Cancer letters
  • This work describes the study of the mechanism of action and spectrum of activity of MR22388, a novel anti-cancer agent belonging to the tripentone series. MR22388 is highly cytotoxic (within the nanomolar range) against numerous cancer cell lines and studies of its cytotoxicity mechanisms show that it is a weak inhibitor of the polymerization of tubulin and that it induces apoptosis via the MAP kinase pathways. Further MR22388 is a very strong inhibitor of several kinases including the… CONTINUE READING
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    References

    SHOWING 1-10 OF 17 REFERENCES
    AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
    • 465
    Design, synthesis, and evaluation of novel thienopyrrolizinones as antitubulin agents.
    • 63
    The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
    • 400
    Mechanism of constitutive activation of FLT3 with internal tandem duplication in the juxtamembrane domain
    • 246
    • PDF
    Biologic and clinical significance of the FLT3 transcript level in acute myeloid leukemia.
    • 233
    • PDF
    Internal tandem duplication of the flt3 gene found in acute myeloid leukemia.
    • 1,130
    A quantitative analysis of kinase inhibitor selectivity
    • 1,960
    • PDF