MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage

@inproceedings{Gold2014MR1restrictedMC,
  title={MR1-restricted MAIT cells display ligand discrimination and pathogen selectivity through distinct T cell receptor usage},
  author={Marielle C Gold and James E. McLaren and Joseph A. Reistetter and Sue Smyk-Pearson and Kristin Ladell and Gwendolyn M. Swarbrick and Yik Y.L. Yu and Ted H. Hansen and Ole Lund and Morten Nielsen and Bram Gerritsen and Can Kesmir and John J. Miles and David M Lewinsohn and David A. Price},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Mucosal-associated invariant T (MAIT) cells express a semi-invariant T cell receptor (TCR) that detects microbial metabolites presented by the nonpolymorphic major histocompatibility complex (MHC)-like molecule MR1. The highly conserved nature of MR1 in conjunction with biased MAIT TCRα chain usage is widely thought to indicate limited ligand presentation and discrimination within a pattern-like recognition system. Here, we evaluated the TCR repertoire of MAIT cells responsive to three classes… CONTINUE READING
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Antimicrobial activity of mucosal - associated invariant T cells

  • L. Le Bourhis, E. Martin, +7 authors V. Premel
  • Nat . Immunol .
  • 2010
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