MR1 presents microbial vitamin B metabolites to MAIT cells
@article{KjerNielsen2012MR1PM, title={MR1 presents microbial vitamin B metabolites to MAIT cells}, author={Lars Kjer-Nielsen and Onisha Patel and Alexandra J. Corbett and J{\'e}r{\^o}me Le Nours and Bronwyn S. Meehan and Ligong Liu and Mugdha Bhati and Zhenjun Chen and Lyudmila Kostenko and Rangsima Reantragoon and Nicholas A. Williamson and Anthony Wayne Purcell and Nadine L. Dudek and Malcolm J. McConville and Richard A. J. O'hair and George N. Khairallah and Dale I. Godfrey and David P. Fairlie and Jamie Rossjohn and James McCluskey}, journal={Nature}, year={2012}, volume={491}, pages={717-723} }
Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based antigens, respectively, for recognition by T cells. Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like T cells in humans that are activated by an antigen(s) bound to the MHC class I-like molecule MR1. Although the identity of MR1-restricted antigen(s) is unknown, it is present in numerous bacteria and yeast. Here we show that the…
955 Citations
MR1 presentation of vitamin B-based metabolite ligands.
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The understanding of how novel antigens are generated is reviewed and their interactions with MR1 and MAIT TCRs are discussed.
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The discovery that MR1 presents vitamin B-based small molecule ligands resulted in a rapid expansion of research in this area, which has yielded information on the role of MAIT cells in immune protection, autoimmune disease and recently in homeostasis and cancer.
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The historical perspective of the MR1/MAIT field is provided before describing the main characteristics of MR1, its ligands, and the few available data regarding its cellular biology and the current knowledge of MAIT cell differentiation is summarized.
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Recognition of vitamin B metabolites by mucosal-associated invariant T cells.
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A structural basis for MAIT TCR recognition of vitamin B metabolites is formally demonstrated, while illuminating how TCRs recognize microbial metabolic signatures.
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It is revealed that in addition to peptide and lipid‐based Ags, small molecule natural product metabolites are also ligands that can activate T cells expressing αβ T‐cell receptors, and here it is recounted this discovery.
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