• DOI:10.1038/nature11605
Corpus ID: 4419703

MR1 presents microbial vitamin B metabolites to MAIT cells

@article{KjerNielsen2012MR1PM,
  title={MR1 presents microbial vitamin B metabolites to MAIT cells},
  author={L. Kjer-Nielsen and O. Patel and A. Corbett and J. L. Nours and B. Meehan and Ligong Liu and M. Bhati and Z. Chen and L. Kostenko and R. Reantragoon and N. Williamson and A. Purcell and N. Dudek and M. McConville and R. O'hair and G. Khairallah and D. Godfrey and D. Fairlie and J. Rossjohn and J. McCluskey},
  journal={Nature},
  year={2012},
  volume={491},
  pages={717-723}
}

• L. Kjer-Nielsen, O. Patel, +17 authors J. McCluskey
• Published 2012
• Biology, Medicine
• Nature

Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptide- and lipid-based antigens, respectively, for recognition by T cells. Mucosal-associated invariant T (MAIT) cells are an abundant population of innate-like T cells in humans that are activated by an antigen(s) bound to the MHC class I-like molecule MR1. Although the identity of MR1-restricted antigen(s) is unknown, it is present in numerous bacteria and yeast. Here we show that the… Expand

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