MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage

  title={MR1 displays the microbial metabolome driving selective MR1-restricted T cell receptor usage},
  author={Melanie J. Harriff and Curtis McMurtrey and Cara A. Froyd and Haihong Jin and Meghan E. Cansler and Megan D. Null and Aneta H. Worley and Erin W. Meermeier and Gwendolyn M. Swarbrick and Aaron Nilsen and Deborah A. Lewinsohn and William H. Hildebrand and Erin J. Adams and David M. Lewinsohn},
  journal={Science immunology},
A diverse array of microbial metabolites binds to MR1 and selectively activates MR1-restricted T cells. A broader repertoire A subset of T cells can detect microbial ligands displayed by MR1, a nonconventional MHC molecule. MR1 is known to present metabolites from microbes like Mycobacterium tuberculosis, but the breadth of the MR1 ligandome is not well understood. Harriff et al. use mass spectrometry and molecular networking to identify MR1-presented ligands from two divergent microbes… 

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