MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution

  title={MR1 antigen presentation to mucosal-associated invariant T cells was highly conserved in evolution},
  author={Shouxiong Huang and Emmanuel Martin and Sojung Kim and Lawrence Yu and Claire Soudais and Daved H. Fremont and Olivier Lantz and Ted. H. Hansen},
  journal={Proceedings of the National Academy of Sciences},
  pages={8290 - 8295}
Several nonclassical major histocompatibilty antigens (class Ib molecules) have emerged as key players in the early immune response to pathogens or stress. Class Ib molecules activate subsets of T cells that mount effector responses before the adaptive immune system, and thus are called innate T cells. MR1 is a novel class Ib molecule with properties highly suggestive of its regulation of mucosal immunity. The Mr1 gene is evolutionarily conserved, is non-Mhc linked, and controls the development… 

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