MR spectroscopy indicates diffuse multiple sclerosis activity during remission.

@article{Kirov2009MRSI,
  title={MR spectroscopy indicates diffuse multiple sclerosis activity during remission.},
  author={Ivan I. Kirov and V Patil and James S. Babb and Henry Rusinek and Joseph Herbert and Ofer Gonen},
  journal={Journal of neurology, neurosurgery, and psychiatry},
  year={2009},
  volume={80 12},
  pages={1330-6}
}
OBJECTIVE To test the hypothesis that diffuse abnormalities precede axonal damage and atrophy in the MRI normal-appearing tissue of relapsing-remitting (RR) multiple sclerosis (MS) patients, and that these processes continue during clinical remission. METHODS Twenty-one recently diagnosed mildly disabled (mean disease duration 2.3 years, mean Expanded Disability Status Scale score of 1.4) RR MS patients and 15 healthy matched controls were scanned with MRI and proton MR spectroscopic imaging… CONTINUE READING

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