MR-spectroscopic findings in juvenile-onset Huntington's disease.

Abstract

Seven HD gene positive individuals under the age of 21 years are described with clinical examination and proton-MR-spectroscopy ((1)H-MRS) profiles of the putamen. Despite clinical variability, the predominate (1)H-MRS abnormality is elevated glutamate, expressed well beyond the confines of the basal ganglia, and low striatal creatine. 
DOI: 10.1002/mds.22245

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