MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.

  title={MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging.},
  author={Franz Fazekas and John B. Chawluk and Abass Alavi and Howard I. Hurtig and Robert A. Zimmerman},
  journal={AJR. American journal of roentgenology},
  volume={149 2},
The type, frequency, and extent of MR signal abnormalities in Alzheimer's disease and normal aging are a subject of controversy. With a 1.5-MR unit we studied 12 Alzheimer patients, four subjects suffering from multiinfarct dementia and nine age-matched controls. Punctate or early confluent high-signal abnormalities in the deep white matter, noted in 60% of both Alzheimer patients and controls, were unrelated to the presence of hypertension or other vascular risk factors. A significant number… 

Figures and Tables from this paper

Lack of difference in brain hyperintensities between patients with early Alzheimer's disease and control subjects.

Tiny hyperintensities on magnetic resonance images are frequent both in patients with early Alzheimer's disease and in healthy controls; most of the lesions are not related to brain ischemia.

MR signal abnormalities in memory disorder and dementia.

MR imaging of the brain, performed in 86 normal subjects and 113 patients with objective memory disorder or dementia, demonstrated white- and gray-matter areas of high signal intensity on long TR

White matter hyperintensities in dementia of Alzheimer's type and in healthy subjects without cerebrovascular risk factors. A magnetic resonance imaging study.

Results suggest that, in subjects screened for cerebrovascular risk factors, WMHIs are rare and occur with identical frequency in patients with DAT as in age-matched healthy control subjects.

Magnetic Resonance Imaging Hyperintensities in Alzheimer's Disease

A disproportionately higher number of patients with more marked ventricular enlargement in the first study appears to be the likeliest explanation for these and there still remains a trend toward more signal abnormalities in Alzheimer's disease, however.

White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors

Both age and severity of dementia were significantly associated with WMCs in AD patients, and these associations highlight future research targets.

Magnetization transfer measurements of the hippocampus in patients with Alzheimer's disease, vascular dementia, and other types of dementia.

MT measurements may be more specific than visual analysis in detecting structural damage of the hippocampus in AD patients and might be useful in discriminating AD from vascular dementia and other types of dementia.

Distinct contribution of white matter damage to the clinical syndrome of Alzheimer's disease

Sensitive diffusion MRI measures were used to determine that the tissue properties of WML slightly differed microstructurally between individuals with Alzheimer's disease and non-demented controls, and were strongly related to ventricular enlargement, and two statistically distinct factors presumed to be due to differing underlying disease processes were discovered.

Clinical correlates of high signal lesions on magnetic resonance imaging in Alzheimer's disease

The findings suggest that periventricular high signal and subcortical white matter lesions are common in patients with AD even when those with evidence of cerebrovascular disease are excluded; their presence should not preclude a diagnosis of AD.



A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study

In cases of Alzheimer's presenile and senile dementia, Alzheimer's disease (AD) andsenile dementia of the Alzheimer type (SDAT), respectively, a lesion that has the character of an incomplete infarction confined to the white matter is observed.

MR imaging of the aging brain: patchy white-matter lesions and dementia.

Magnetic resonance (MR) imaging studies of the brain in five elderly patients with non-Alzheimer dementia were compared with those in two groups of nondemented control subjects. Group 1 included five

Leukoencephalopathy in normal and pathologic aging: 2. MRI of brain lucencies.

Results indicated that MR was more sensitive than CT to parenchymal disease, but the extent of white-matter involvement was greater in the Alzheimer group.

Decreased computerized tomography numbers in patients with presenile dementia. Detection in patients with otherwise normal scans.

Differential diagnosis between dementia and depression may be better aided by studying the CT numbers rather than the presence of prominent sulci, which are higher for six nondementia cases than for 14 dementia cases.

Parenchymal CT correlates of senile dementia (Alzheimer disease): loss of gray-white matter discriminability.

This investigation suggests that loss of gray-white matter discriminability by computed tomography (CT) is related to cognitive impairment in senile dementia (Alzheimer disease), and nogray-white discriminabilities correlation with age was demonstrated suggesting that gray- white discriminable does not simply change with age.

Cerebral NMR and CT Imaging in Dementia

Thirteen patients with different types of dementia were studied with nuclear magnetic resonance (NMR) and CT imaging of the brain and it was difficult to distinguish between the lacunar state type and Binswanger type of vascular dementia.

Subcortical arteriosclerotic encephalopathy (Binswanger's disease). Computed tomographic, nuclear magnetic resonance, and clinical correlations.

Twenty-three elderly patients were found to have a consistent pattern of leukoencephalopathy by computed tomography and nuclear magnetic resonance imaging, and the necropsy of one patient revealed arteriosclerotic vasculopathy characteristic of subcortical arteriosclerosis encephalopathy (SAE) or Binswanger's disease.

Periventricular hyperintensity as seen by magnetic resonance: prevalence and significance.

The pattern of periventricular hyperintensity has proven to be of limited value in the clinical assessment of hydrocephalic patients and should be considered indicative of either demyelinating disease or hydrocephalus.

Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes.

CAA was most severe in cases of Alzheimer's disease, but occurred in the absence of this condition, and was of greater severity in the parietal and occipital gray matter.

Pathological verification of ischemic score in differentiation of dementias

Fourteen case histories of persons who had a histological diagnosis of either senile dementia of the Alzheimer type, multiinfarct dementia, or a mixed dementia composed of these two types and who