MR molecular imaging of prostate cancer with a small molecular CLT1 peptide targeted contrast agent.

@article{Wu2013MRMI,
  title={MR molecular imaging of prostate cancer with a small molecular CLT1 peptide targeted contrast agent.},
  author={Xueming Wu and Daniel J. Lindner and Guan-Ping Yu and Susann M Brady-Kalnay and Zheng-Rong Lu},
  journal={Journal of visualized experiments : JoVE},
  year={2013},
  volume={79}
}
Tumor extracellular matrix has abundance of cancer related proteins that can be used as biomarkers for cancer molecular imaging. In this work, we demonstrated effective MR cancer molecular imaging with a small molecular peptide targeted Gd-DOTA monoamide complex as a targeted MRI contrast agent specific to clotted plasma proteins in tumor stroma. We performed the experiment of evaluating the effectiveness of the agent for non-invasive detection of prostate tumor with MRI in a mouse orthotopic… CONTINUE READING