MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis.

@article{Ahrens1998MRMO,
  title={MR microscopy of transgenic mice that spontaneously acquire experimental allergic encephalomyelitis.},
  author={Eric T. Ahrens and David H. Laidlaw and Carol Readhead and Celia F. Brosnan and Scott E. Fraser and Russell E. Jacobs},
  journal={Magnetic resonance in medicine},
  year={1998},
  volume={40 1},
  pages={119-32}
}
Pathology of fixed spinal cords from transgenic mice with a myelin basic protein (MBP) specific T cell receptor was investigated. These mice spontaneously acquire the demyelinating disease experimental allergic encephalomyelitis (EAE). Several complementary imaging modalities, all on the same tissues, were used to visualize lesions; these included high-field (11.7-T) microscopic diffusion tensor imaging (DTI), T2*-weighted imaging, and optical microscopy on histological sections. Lesions were… CONTINUE READING

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Lesions were predominantly in white matter around meninges and vasculature and appeared hyperintense in anatomical images .
Lesions were predominantly in white matter around meninges and vasculature and appeared hyperintense in anatomical images .
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