MR measurement of intracranial CSF volume in 41 elderly normal volunteers.

Abstract

A noninvasive nonplanimetric MR protocol was used to measure the total intracranial CSF volume in 41 normal subjects, aged 60-84 years, who were intensively screened to eliminate CNS disease. The protocol entailed application of MR imaging data acquired with a spin-echo sequence in a single thick slice encompassing the head. The results show a strong correlation between increased intracranial CSF volume and increasing age, and a weaker correlation between increased intracranial CSF volume and increasing total intracranial volume. The possibility of employing a CSF volume measurement as a reflection of brain atrophy to help diagnose dementia is discussed.

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@article{Malko1991MRMO, title={MR measurement of intracranial CSF volume in 41 elderly normal volunteers.}, author={John A. Malko and J. Hoffman and Robert C. Green}, journal={AJNR. American journal of neuroradiology}, year={1991}, volume={12 2}, pages={371-4} }