MR in mouse models of cardiac disease.

  title={MR in mouse models of cardiac disease.},
  author={F. H. Epstein},
  journal={NMR in biomedicine},
  volume={20 3},
Transgenic and knockout mice can be used to study the genes and basic mechanisms involved in heart disease, and have therefore assumed a central role in modern cardiac research. MRI and MRS techniques have recently been developed for mice that enable the quantitative or semi-quantitative in vivo assessment of cardiac anatomy, function, perfusion, infarction, Ca(2+) influx, and metabolism. With these techniques, the normal mouse heart has been shown to be well suited as a model of human cardiac… CONTINUE READING

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