MR imaging and proton MR spectroscopy in adult Krabbe disease.

  title={MR imaging and proton MR spectroscopy in adult Krabbe disease.},
  author={Lucia Farina and Alberto Bizzi and Gaetano Finocchiaro and Davide Pareyson and Angelo Sghirlanzoni and Barbara Bertagnolio and Mario Savoiardo and Sakkubai R Naidu and Bhim Sen Singhal and David A. Wenger},
  journal={AJNR. American journal of neuroradiology},
  volume={21 8},
We present the MR imaging findings in four patients (two pairs of siblings from two unrelated families) with adult Krabbe disease. In the first family, clinical presentation mimicked familial spastic paraplegia. Their MR images showed selective, increased signal intensity on T2-weighted sequences along the corticospinal tracts, most prominently in the proband and barely detectable in her brother. Proton MR spectroscopy showed increased choline and myo-inositol in the affected white matter. In… CONTINUE READING
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