MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution.

@article{Meltzer1996MRbasedCO,
  title={MR-based correction of brain PET measurements for heterogeneous gray matter radioactivity distribution.},
  author={Carolyn C. Meltzer and Jon Kar Zubieta and Jonathan M. Links and Paul R. Brakeman and Martin J Stumpf and James Frost},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1996},
  volume={16 4},
  pages={650-8}
}
Partial volume and mixed tissue sampling errors can cause significant inaccuracy in quantitative positron emission tomographic (PET) measurements. We previously described a method of correcting PET data for the effects of partial volume averaging on gray matter (GM) quantitation; however, this method may incompletely correct GM structures when local tissue concentrations are highly heterogeneous. We have extended this three-compartment algorithm to include a fourth compartment: a GM volume of… CONTINUE READING

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