MR Technical Developments for Clinical Hyperpolarized C-Pyruvate Studies in Prostate Cancer Patients

Abstract

Introduction: MR imaging with hyperpolarized [1-C]-pyruvate has the unprecedented ability to rapidly probe cellular metabolic pathways and is a potentially valuable clinical tool, particularly for cancer imaging [1]. Detection of the conversion of hyperpolarized [1C]-pyruvate to hyperpolarized [1-C]-lactate has enabled the demonstration of elevated lactate in animal models of cancer –including prostate cancer – which correlates with pathologic tumor grade [2]. The goal of this project was to develop and test specialized RF coils and MR methods for a Phase 1 clinical trial of hyperpolarized carbon-13 MR studies in prostate cancer patients.

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@inproceedings{Larson2009MRTD, title={MR Technical Developments for Clinical Hyperpolarized C-Pyruvate Studies in Prostate Cancer Patients}, author={Paul E Larson and Jennifer Tropp and Albert Y. P. Chen and Philip Calderon and Shing-yang Hu and Galen Reed and Sarah J. Nelson and John Kurhanewicz and Ralph E. Hurd and Daniel B. Vigneron}, year={2009} }