MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway.

@article{Ren2008MR1MP,
  title={MR-1 modulates proliferation and migration of human hepatoma HepG2 cells through myosin light chains-2 (MLC2)/focal adhesion kinase (FAK)/Akt signaling pathway.},
  author={Kaihuan Ren and Haixia Jin and Chunjing Bian and Hongwei He and Xia Liu and Shenghua Zhang and Yiguang Wang and Rong-guang Shao},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 51},
  pages={35598-605}
}
The key of cell migration process on solid substrates is phosphorylation of myosin light chain-2 (MLC2), which is implicated in a variety of intracellular functions. The previous data show that MLC2 interacts with a novel human gene, myofibrillogenesis regulator 1 (MR-1). Here, we reported that MR-1 was specially overexpressed in human hepatoma HepG2 cells. Transient treatment of cells with small interfering RNA (siRNA) against MR-1 or stable transfection of cells with plasmid expressing MR-1… CONTINUE READING

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