MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain.

@article{Lofrumento2011MPTPinducedNI,
  title={MPTP-induced neuroinflammation increases the expression of pro-inflammatory cytokines and their receptors in mouse brain.},
  author={Dario Domenico Lofrumento and Concetta Saponaro and Antonia Cianciulli and Francesco De Nuccio and Vincenzo Mitolo and Giuseppe Nicolardi and Maria Antonietta Panaro},
  journal={Neuroimmunomodulation},
  year={2011},
  volume={18 2},
  pages={79-88}
}
Parkinson's disease (PD) is a common neurodegenerative disease characterised by a slow and progressive degeneration of dopaminergic neurons in the substantia nigra (SN). Despite intensive research, the cause of neuronal loss in PD is poorly understood. Inflammatory mechanisms have been implicated in the pathophysiology of PD. In this study, conducted on an experimental 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model, we investigated the expression of interleukin (IL)-1β, tumor… CONTINUE READING
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