MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/B16 mice

@article{Chen1995MPPSA,
  title={MPP+ selectively affects calcium homeostasis in mesencephalic cell cultures from embryonal C57/B16 mice},
  author={Theresa S Chen and Eleni Koutsilieri and Wolf Dieter Rausch},
  journal={Journal of Neural Transmission / General Section JNT},
  year={1995},
  volume={100},
  pages={153-163}
}
1-Methyl-4-phenylpyridinium (MPP+), the active metabolite of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) serves as a valuable tool in animal models of Parkinson's disease. Primary cell cultures of mesencephalon from C57/B16 mice were used to investigate the effects of various dopaminergic neurotoxins on the intracellular calcium metabolism. MPP+ was compared to its precursor MPTP and a structural analogue paraquat (methylviologen). Direct addition of these neurotoxins (10 μM) to fura-2… CONTINUE READING

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