MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration.

  title={MPP+-induced COX-2 activation and subsequent dopaminergic neurodegeneration.},
  author={Tongguang Wang and Zhong Pei and Wei Zhang and Bin Liu and Robert I Langenbach and Christopher Y Lee and Belinda C. Wilson and Jeffrey M Reece and David Scott Miller and Jau-Shyong Hong},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={19 9},
The importance of cyclooxygenase-2 (COX-2) in mediating Parkinson's disease (PD) was suggested in reports, indicating that COX-2 selective inhibitors or genetic knockout reduce 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic (DA) neurotoxicity in a mouse model of PD. However, cell types and mechanisms underlying the activation of COX-2 have not been clearly elucidated in these animal studies. Using primary neuron-glia cultures, we aimed to determine 1) whether microglia… CONTINUE READING


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