MPO-ANCA necrotizing glomerulonephritis related to rheumatoid arthritis.


Two patients with rheumatoid arthritis (RA) developed necrotizing crescentic glomerulonephritis with high titers of anti-myeloperoxidase antibodies (MPO) in the absence of overt extrarenal vasculitis. We therefore suggest that in some patients with RA, MPO-ANCA necrotizing glomerulonephritis (GN) may occur as a kidney-limited form of rheumatoid vasculitis, and that RA should be added to the list of diseases potentially associated with necrotizing GN with anti-MPO antibodies. These observations also point out the importance of repeatedly evaluating titers of anti-MPO antibodies in the course of RA, especially if renal impairment or abnormal urinary sediment are present.

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@article{Messiaen1998MPOANCANG, title={MPO-ANCA necrotizing glomerulonephritis related to rheumatoid arthritis.}, author={Thomas Messiaen and Pauline M'bapp{\'e} and Jean Jacques Boffa and Rami N. Khayat and B{\'e}atrice Mougenot and J{\'e}r{\^o}me A Rossert and Pierre Marie Ronco}, journal={American journal of kidney diseases : the official journal of the National Kidney Foundation}, year={1998}, volume={32 5}, pages={E6} }