MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia

@article{Pikman2006,
  title={
					MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
				},
  author={Yana Pikman and Benjamin Howard Lee and Thomas Mercher and Elizabeth P. McDowell and Benjamin L. Ebert and Maricel C. Gozo and Adam Cuker and Gerlinde Wernig and Sandra Moore and Ilene Galinsky and Daniel J. Deangelo and Jennifer J Clark and Stephanie J Lee and Todd R. Golub and Martha Wadleigh and Dwight Gary Gilliland and Ross L. Levine},
  journal={PLoS Medicine},
  year={2006},
  volume={3},
  pages={372 - 375}
}
BACKGROUND The JAK2V617F allele has recently been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF). Subsequent analysis has shown that constitutive activation of the JAK-STAT signal transduction pathway is an important pathogenetic event in these patients, and that enzymatic inhibition of JAK2V617F may be of therapeutic benefit in this context. However, a significant proportion of patients with ET or MF are… CONTINUE READING
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