MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.

@article{Sheikh2015MOZAB,
  title={MOZ and BMI1 play opposing roles during Hox gene activation in ES cells and in body segment identity specification in vivo.},
  author={Bilal N. Sheikh and Natalie L. Downer and Belinda Phipson and Hannah Kate Vanyai and Andrew J Kueh and Davis James McCarthy and Gordon K Smyth and Tim Thomas and Anne Kathrin Voss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2015},
  volume={112 17},
  pages={5437-42}
}
Hox genes underlie the specification of body segment identity in the anterior-posterior axis. They are activated during gastrulation and undergo a dynamic shift from a transcriptionally repressed to an active chromatin state in a sequence that reflects their chromosomal location. Nevertheless, the precise role of chromatin modifying complexes during the initial activation phase remains unclear. In the current study, we examined the role of chromatin regulators during Hox gene activation. Using… CONTINUE READING
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