MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators.

@article{Collins2006MOZTIF2AC,
  title={MOZ-TIF2 alters cofactor recruitment and histone modification at the RARbeta2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators.},
  author={Hilary Collins and Karin B. Kindle and Sachiko Matsuda and Colm M. Ryan and Philip J F Troke and Eric Kalkhoven and David M Heery},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 25},
  pages={17124-33}
}
MOZ-TIF2 and MOZ-CBP are leukemogenic fusion proteins associated with therapy-induced acute myeloid leukemia. These proteins are thought to subvert normal gene expression in differentiating hematopoietic progenitor cells. We have previously shown that MOZ-TIF2 inhibits transcription by CREB-binding protein (CBP)/p300-dependent activators such as nuclear receptors and p53. Here we have shown that MOZ-TIF2 associates with the RARbeta2 promoter in vivo, resulting in altered recruitment of CBP/p300… CONTINUE READING