MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells

@inproceedings{Carlier2012MOSAICAM,
  title={MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells},
  author={Aur{\'e}lie Carlier and Liesbet Geris and Katie Bentley and Geert Carmeliet and Peter Carmeliet and Hans Van Oosterwyck},
  booktitle={PLoS Computational Biology},
  year={2012}
}
The healing of a fracture depends largely on the development of a new blood vessel network (angiogenesis) in the callus. During angiogenesis tip cells lead the developing sprout in response to extracellular signals, amongst which vascular endothelial growth factor (VEGF) is critical. In order to ensure a correct development of the vasculature, the balance between stalk and tip cell phenotypes must be tightly controlled, which is primarily achieved by the Dll4-Notch1 signaling pathway. This… CONTINUE READING
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