MORG1+/− mice are protected from histological renal damage and inflammation in a murine model of endotoxemia

@article{Bondeva2018MORG1MA,
  title={MORG1+/− mice are protected from histological renal damage and inflammation in a murine model of endotoxemia},
  author={T. Bondeva and Claudia Schindler and Katrin Schindler and G. Wolf},
  journal={BMC Nephrology},
  year={2018},
  volume={19}
}
  • T. Bondeva, Claudia Schindler, +1 author G. Wolf
  • Published 2018
  • Medicine
  • BMC Nephrology
  • BackgroundThe MAPK-organizer 1 (MORG1) play a scaffold function in the MAPK and/or the PHD3 signalling paths. Recently, we reported that MORG1+/− mice are protected from renal injury induced by systemic hypoxia and acute renal ischemia-reperfusion injury via increased hypoxia-inducible factors (HIFs). Here, we explore whether MORG1 heterozygosity could attenuate renal injury in a murine model of lipopolysaccharide (LPS) induced endotoxemia.MethodsEndotoxemia was induced in mice by an… CONTINUE READING
    2 Citations

    References

    SHOWING 1-10 OF 52 REFERENCES
    Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury.
    • 23
    Preconditioned suppression of prolyl-hydroxylases attenuates renal injury but increases mortality in septic murine models.
    • 9
    • PDF
    Erythropoietin attenuates acute kidney dysfunction in murine experimental sepsis by activation of the β-common receptor.
    • 62
    • Highly Influential
    • PDF
    Morg1 heterozygous deficiency ameliorates hypoxia-induced acute renal injury.
    • 5
    • PDF
    Morg1+/− heterozygous mice are protected from experimentally induced focal cerebral ischemia
    • 10
    Inhibition of hypoxia inducible factor hydroxylases protects against renal ischemia-reperfusion injury.
    • 215
    • PDF