MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD

@inproceedings{Nieratschker2014MORC1EC,
  title={MORC1 exhibits cross-species differential methylation in association with early life stress as well as genome-wide association with MDD},
  author={Vanessa Nieratschker and Renaud Massart and M Gilles and Alessia Luoni and Matthew J. Suderman and Bertram Krumm and Sarah Meier and Stephanie H. Witt and Markus M. N{\"o}then and Stephen J. Suomi and Verena Peus and Barbara Scharnholz and Helene Dukal and C Hohmeyer and Isabell A. C. Wolf and Francesca Cirulli and Peter Gass and M W S{\"u}tterlin and Barbara Filsinger and Manfred Laucht and Marco Andrea Riva and Marcella Rietschel and Michael Deuschle and Moshe Szyf},
  booktitle={Translational Psychiatry},
  year={2014}
}
Early life stress (ELS) is associated with increased vulnerability for diseases in later life, including psychiatric disorders. Animal models and human studies suggest that this effect is mediated by epigenetic mechanisms. In humans, epigenetic studies to investigate the influence of ELS on psychiatric phenotypes are limited by the inaccessibility of living brain tissue. Due to the tissue-specific nature of epigenetic signatures, it is impossible to determine whether ELS induced epigenetic… CONTINUE READING
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