MORC family ATPases required for heterochromatin condensation and gene silencing.

  title={MORC family ATPases required for heterochromatin condensation and gene silencing.},
  author={Guillaume Moissiard and Shawn Cokus and Joshua Cary and Suhua Feng and Allison C. Billi and Hume Stroud and Dylan Husmann and Ye Zhan and Bryan R. Lajoie and Rachel Patton McCord and Christopher J. Hale and Wei Feng and Scott D. Michaels and Alison R. Frand and Matteo Pellegrini and Job Dekker and John K. Kim and Steven E. Jacobsen},
  volume={336 6087},
Transposable elements (TEs) and DNA repeats are commonly targeted by DNA and histone methylation to achieve epigenetic gene silencing. We isolated mutations in two Arabidopsis genes, AtMORC1 and AtMORC6, which cause derepression of DNA-methylated genes and TEs but no losses of DNA or histone methylation. AtMORC1 and AtMORC6 are members of the conserved Microrchidia (MORC) adenosine triphosphatase (ATPase) family, which are predicted to catalyze alterations in chromosome superstructure. The… CONTINUE READING
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MORC Family ATPases Required for Heterochromatin Condensation and Gene Silencing

  • G. Moissiard, S. J. Cokus, +15 authors S. E. Jacobsen
  • Science
  • 2012
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