MONOCYTE/MACROPHAGE PROCOAGULANT ACTIVITY AS A MEASURE OF IMMUNE RESPONSIVENESS IN LEWIS AND BROWN NORWAY INBRED RATS

@article{Silverman1989MONOCYTEMACROPHAGEPA,
  title={MONOCYTE/MACROPHAGE PROCOAGULANT ACTIVITY AS A MEASURE OF IMMUNE RESPONSIVENESS IN LEWIS AND BROWN NORWAY INBRED RATS},
  author={R. Silverman and Z. Cohen and M. Craig and A. Wakefield and P. Kim and B. Langer and G. Levy},
  journal={Transplantation},
  year={1989},
  volume={47},
  pages={542–547}
}
In vitro lymphocyte proliferative assays were performed using Lewis (Lew) and Brown Norway (BN) rats, and compared to induction of monocyte/macrophage procoagulant activity (PCA) in a mixed lymphocyte culture and by endotoxin (LPS) (E. Coli 0111:B4). Splenic mononuclear cells from Lew rats had significantly greater mitogen-induced proliferation to concanavalin A (P = .002) and phytohemagglutinin (P = 0.007). The Lew cells also showed greater allogeneically induced proliferation by BN cells in a… Expand
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