MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY

@article{Press1973MONOCLONALPO,
  title={MONOCLONAL PRODUCTION OF BOTH IgM AND IgG1 ANTIHAPTEN ANTIBODY},
  author={Joan L. Press and Norman R. Klinman},
  journal={The Journal of Experimental Medicine},
  year={1973},
  volume={138},
  pages={300 - 305}
}
The anti-DNP antibodies produced by primary and secondary splenic foci were analyzed for heavy chain class by a radioimmunoassay, using iodinated, purified goat antimouse micro-chain antibody and goat antimouse gamma1 chain antibody. The frequency of primary and secondary foci producing both IgM and IgG1 anti-DNP antibody (16% and 14%, respectively) was considerably higher than that which would be predicted by a random distribution. It would thus appear that IgM and IgG1 antibody can be made by… CONTINUE READING
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Immunoglobulins on lymphocyte membranes

  • B. Pernis, M. Ferrarini, L. Forni, L. Amante
  • In Progress in Immunology. B. Amos,
  • 1971

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