• Corpus ID: 31376364

MOLECULAR CHARACTERISTICS OF RIFAMPIN RESISTANCE AMONG MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED IN NORTHEAST OF IRAN

@inproceedings{Ghazvini2015MOLECULARCO,
  title={MOLECULAR CHARACTERISTICS OF RIFAMPIN RESISTANCE AMONG MYCOBACTERIUM TUBERCULOSIS STRAINS ISOLATED IN NORTHEAST OF IRAN},
  author={Kiarash Ghazvini and Mohammad H. Derakhshan and Hamidreza Bahrami-Taghanaki and Saeed Amel Jamehdar and Nafiseh Izadi},
  year={2015}
}
Background: Emergence of drug-resistant tuberculosis complicated the Tuberculosis Control programs seriously. Rifampin is a marker forMDR-TB therefore, characterizing and designing suitable target for rapid and simple molecular detection of resistance against rifampin is an urgent need. Method: Based on proportional method, fifteen rifampin-resistant isolates of Mycobacterium tuberculosis were identified in northeast of Iranduring July 2012 to May 2013. Phenotypic characterization and genotypic… 
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References

SHOWING 1-10 OF 27 REFERENCES

Molecular Characteristics of Rifampin- and Isoniazid-Resistant Mycobacterium tuberculosis Strains Isolated in Vietnam

TLDR
This study provided the first molecular characterization of INH and RIF resistance of M. tuberculosis strains from Vietnam, and detection of the katG and rpoB mutations of the INH or RIF-resistant strains should be useful for rapid detection of these strains by molecular tests.

Molecular characterization of the rpoB gene mutations of Mycobacterium tuberculosis isolated from China

TLDR
About 98% of RIF-resistant strains isolated from China carry mutations in RRDR of the ropB gene, which provides valuable information in adopting new molecular methods for diagnosis of TB in China.

High-Level Rifampin Resistance Correlates with Multiple Mutations in the rpoB Gene of Pulmonary Tuberculosis Isolates from the Afghanistan Border of Iran

TLDR
It is demonstrated that the combination of mutations with more prevalent nucleotide changes were observed in codons 523, 526, and 531, indicating higher frequencies of mutations among patients with secondary infection, and an association with higher levels of resistance to rifampin.

Molecular characterization of rifampin- and isoniazid-resistant Mycobacterium tuberculosis strains isolated in Poland.

TLDR
The real-time PCR method is fast and reliable for the detection of RMP and INH resistance-associated mutations in M. tuberculosis clinical isolates and five new alleles were described.

Rapid Detection of Isoniazid, Rifampin, and Ofloxacin Resistance in Mycobacterium tuberculosis Clinical Isolates Using High-Resolution Melting Analysis

TLDR
High-resolution melting analysis (HRMA) is a rapid, sensitive method for detection of drug resistance in M. tuberculosis which could be used routinely for screening isolates in countries with a high prevalence of tuberculosis and drug resistance or in individual isolates when drug resistance is suspected.

Fast test for assessing the susceptibility of Mycobacterium tuberculosis to isoniazid and rifampin by real-time PCR.

TLDR
Assessment of RT-PCR compared to traditional culture-based methods for determining the drug susceptibility of M. tuberculosis confirmed that RT- PCR can detect INH and RIF resistance in less than four hours with high sensitivity.

Rapid Detection of Multidrug-Resistant Mycobacterium tuberculosis by Use of Real-Time PCR and High-Resolution Melt Analysis

TLDR
This method provides a rapid, robust, and inexpensive way to detect the dominant mutations known to confer MDR in M. tuberculosis strains and offers several advantages over current molecular and culture-based techniques.

Detection of rifampin resistance patterns in Mycobacterium tuberculosis strains isolated in Iran by polymerase chain reaction-single-strand conformation polymorphism and direct sequencing methods.

TLDR
The data support the common notion that rifampin resistance genotypes are generally present mutations in codons 531 and 526, most frequently found in M. tuberculosis populations regardless of geographic origin.

Study of Genetic Evolution in Mycobacterium tuberculosis Isolates from Patients with Active Pulmonary Tuberculosis in the Iran and Belarus

TLDR
The genetic patterns of samples collected in the first survey of anti-tuberculosis drug-resistance by gene coding of RNA polymerase as part of the international project of on tuberculosis are researched to give a first result on genetic evolution of the M. tuberculosis strains distributing in Iran and Belarus.

Molecular analysis of isoniazid resistance in different genotypes of Mycobacterium tuberculosis isolates from Iran.

TLDR
Analysis of isoniazid resistance in Iranian Mycobacterium tuberculosis isolates revealed that most of the isolates containing ahpC46A and katG 463Leu polymorphism belonged to the Central Asian (CAS) super family, which highlights the importance of the CAS super family in INH resistance in Iran.