MOF-associated complexes ensure stem cell identity and Xist repression

@article{Chelmicki2014MOFassociatedCE,
  title={MOF-associated complexes ensure stem cell identity and Xist repression},
  author={Tomasz Chelmicki and F. D{\"u}ndar and M. J. Turley and T. Khanam and Tuğçe Aktaş and F. Ram{\'i}rez and Anne-Valerie Gendrel and Patrick R. Wright and Pavankumar Videm and R. Backofen and E. Heard and T. Manke and A. Akhtar},
  journal={eLife},
  year={2014},
  volume={3}
}
Histone acetyl transferases (HATs) play distinct roles in many cellular processes and are frequently misregulated in cancers. Here, we study the regulatory potential of MYST1-(MOF)-containing MSL and NSL complexes in mouse embryonic stem cells (ESCs) and neuronal progenitors. We find that both complexes influence transcription by targeting promoters and TSS-distal enhancers. In contrast to flies, the MSL complex is not exclusively enriched on the X chromosome, yet it is crucial for mammalian X… Expand
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