MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair

@article{Sharma2010MOFAH,
  title={MOF and Histone H4 Acetylation at Lysine 16 Are Critical for DNA Damage Response and Double-Strand Break Repair},
  author={G. Sharma and Sairei So and Arun Gupta and Rakesh Kumar and Christelle Cayrou and N. Avvakumov and U. Bhadra and R. Pandita and M. Porteus and David J. Chen and J. C{\^o}t{\'e} and T. Pandita},
  journal={Molecular and Cellular Biology},
  year={2010},
  volume={30},
  pages={3582 - 3595}
}
ABSTRACT The human MOF gene encodes a protein that specifically acetylates histone H4 at lysine 16 (H4K16ac). Here we show that reduced levels of H4K16ac correlate with a defective DNA damage response (DDR) and double-strand break (DSB) repair to ionizing radiation (IR). The defect, however, is not due to altered expression of proteins involved in DDR. Abrogation of IR-induced DDR by MOF depletion is inhibited by blocking H4K16ac deacetylation. MOF was found to be associated with the DNA… Expand
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