MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.

@article{Li2010MOFAH,
  title={MOF and H4 K16 acetylation play important roles in DNA damage repair by modulating recruitment of DNA damage repair protein Mdc1.},
  author={Xiangzhi Li and Callie Ann Sprunger Corsa and Patricia W. Pan and Lipeng Wu and David Ferguson and Xiaochun Yu and Jinrong Min and Yali Dou},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 22},
  pages={
          5335-47
        }
}
MOF (MYST1) is the major enzyme to catalyze acetylation of histone H4 lysine 16 (K16) and is highly conserved through evolution. Using a conditional knockout mouse model and the derived mouse embryonic fibroblast cell lines, we showed that loss of Mof led to a global reduction of H4 K16 acetylation, severe G(2)/M cell cycle arrest, massive chromosome aberration, and defects in ionizing radiation-induced DNA damage repair. We further showed that although early DNA damage sensing and signaling by… CONTINUE READING
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