MOCASSIN-prot: a multi-objective clustering approach for protein similarity networks

@article{Keel2018MOCASSINprotAM,
  title={MOCASSIN-prot: a multi-objective clustering approach for protein similarity networks},
  author={Brittney N. Keel and Bo Deng and Etsuko N. Moriyama},
  journal={Bioinformatics},
  year={2018},
  volume={34 8},
  pages={
          1270-1277
        }
}
Motivation Proteins often include multiple conserved domains. Various evolutionary events including duplication and loss of domains, domain shuffling, as well as sequence divergence contribute to generating complexities in protein structures, and consequently, in their functions. The evolutionary history of proteins is hence best modeled through networks that incorporate information both from the sequence divergence and the domain content. Here, a game-theoretic approach proposed for protein… CONTINUE READING
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