MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects

@article{Jilek2012MOBPspecificCI,
  title={MOBP-specific cellular immune responses are weaker than MOG-specific cellular immune responses in patients with multiple sclerosis and healthy subjects},
  author={Samantha Jilek and Myriam Schluep and Giuseppe Pantaleo and Renaud A. Du Pasquier},
  journal={Neurological Sciences},
  year={2012},
  volume={34},
  pages={539-543}
}
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS). Myelin oligodendrocyte glycoprotein (MOG) and myelin oligodendrocyte basic protein (MOBP) were both shown to be highly encephalitogenic in animal models of MS. In contrast, the association of MOG- and MOBP-specific humoral or cellular immune responses and MS in humans is far less established. In this study, we sought to analyse MOG- and MOBP-specific T-cell responses in a large cohort of… CONTINUE READING

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