MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL

@inproceedings{Landon2014MNKsAA,
  title={MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL},
  author={Ari L. Landon and Parameswary A. Muniandy and Amol Carl Shetty and Elin Lehrmann and Laurent Volpon and Simone Houng and Yongqing Zhang and Bojie Dai and Raymond Peroutka and Krystyna Mazan-Mamczarz and James J. Steinhardt and Anup A. Mahurkar and Kevin G. Becker and Katherine L B Borden and Ronald B. Gartenhaus},
  booktitle={Nature communications},
  year={2014}
}
The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and MNK2 in germinal centre B-cell (GCB) and activated B-cell (ABC) DLBCL. Despite displaying a differential distribution in GCB and ABC, both MNKs functionally complement each other to sustain cell… CONTINUE READING

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