MN1 overexpression is an important step in the development of inv(16) AML

@article{Carella2007MN1OI,
  title={MN1 overexpression is an important step in the development of inv(16) AML},
  author={Cintia Carella and J. L. G. Bonten and Sema Sirma and Tanya A Kranenburg and Sabrina Terranova and Ramon I. Klein-Geltink and Sheila Shurtleff and James R. Downing and Ellen C. Zwarthoff and Pu Paul Liu and Gerard C Grosveld},
  journal={Leukemia},
  year={2007},
  volume={21},
  pages={1679-1690}
}
The gene encoding the transcriptional co-activator MN1 is the target of the reciprocal chromosome translocation (12;22)(p13;q12) in some patients with acute myeloid leukemia (AML). In addition, expression array analysis showed that MN1 was overexpressed in AML specified by inv(16), in some AML overexpressing ecotropic viral integration 1 site (EVI1) and in some AML without karyotypic abnormalities. Here we describe that mice receiving transplants of bone marrow (BM) overexpressing MN1 rapidly… CONTINUE READING
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