MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.

@article{Ito2010MMXDAT,
  title={MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation.},
  author={Shinsuke Ito and Li Jing Tan and Daisuke Andoh and Takashi Narita and Mineaki Seki and Yasuhiro Hirano and Keiko Narita and Isao Kuraoka and Yasushi Hiraoka and Kiyoji Tanaka},
  journal={Molecular cell},
  year={2010},
  volume={39 4},
  pages={632-40}
}
Xeroderma pigmentosum group D (XPD) protein is one of the subunits of TFIIH that is required for nucleotide excision repair and transcription. We found a XPD protein complex containing MMS19 that was assumed to be a regulator of TFIIH. However, the MMS19-XPD complex did not contain any other subunits of TFIIH. Instead, it included FAM96B (now designated MIP18), Ciao1, and ANT2. MMS19, MIP18, and XPD localized to the mitotic spindle during mitosis. The siRNA-mediated knockdown of MMS19, MIP18… CONTINUE READING

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