MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein.


Aggrecan degradation in articular cartilage occurs predominantly through proteolysis and has been attributed to the action of members of the matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) families. Both families of enzymes cleave aggrecan at specific sites within the aggrecan core protein. One… (More)
DOI: 10.1016/j.matbio.2010.10.007


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