MMPs: a novel drug target for schizophrenia.

  title={MMPs: a novel drug target for schizophrenia.},
  author={Kanwaljit Chopra and Ankita Baveja and Anurag Kuhad},
  journal={Expert opinion on therapeutic targets},
  volume={19 1},
INTRODUCTION Schizophrenia, a multifactorial disorder, is associated with dopaminergic hyperactivity, dysregulated glutamatergic neurotransmission, neuroinflammation and extracellular matrix (ECM) disturbances. MMPs, a group of structurally related proteolytic enzymes, are responsible for remodeling of ECM that maintains synaptic functions and blood-brain barrier (BBB) patency. Overstimulation of MMPs by neuroinflammation triggers ECM abnormalities that directly or indirectly alter neuronal… CONTINUE READING