MMPR in combination with 6-mercaptopurine is effective in inducing remission in adults with acute myelogenous leukemia

Abstract

MMPR2 is an adenosine analog with substantial antitumor activity in experimental systems (1 , 12). It is not cross resistant with 6-mercaptopurine; Le., it maintains its activity in Ll210 mouse leukemia and human cancer cells in culture, which are resistant to 6-mercaptopurine (2, 4). The biochem ical basis for this lack of cross-resistance has been… (More)

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