MMP7 and MMP8 genetic polymorphisms in bladder cancer patients

MMP7 and MMP8 genetic polymorphisms in bladder cancer patients},
  author={Edyta Wieczorek and Edyta Reszka and Wojciech Wąsowicz and Adam Grzegorczyk and Tomasz Konecki and Marek Sosnowski and Zbigniew Jablonowski},
  booktitle={Central European journal of urology},
INTRODUCTION Breakdown of the extracellular matrix by matrix metalloproteinases (MMPs), as we know, is one of mechanisms involved and required in tumor invasion. MMP7 is a negative prognostic factor of various malignances, while MMP8 exhibits an inhibitory effect on tumorigenesis and metastasis. We evaluated the potential association of functional polymorphisms in the promoter of the MMP7 (rs11568818) and MMP8 (rs11225395) genes and bladder cancer (BCa) risk. MATERIALS AND METHODS The study… CONTINUE READING


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Matrix metalloproteinases and their clinical relevance in urinary bladder cancer

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nat rev Urol • 2011

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