MMP7 Shedding of Syndecan-1 Facilitates Re-Epithelialization by Affecting α2β1 Integrin Activation

@inproceedings{Chen2009MMP7SO,
  title={MMP7 Shedding of Syndecan-1 Facilitates Re-Epithelialization by Affecting α2β1 Integrin Activation},
  author={Peter Chen and Laura E. Abacherli and Samuel T. Nadler and Ying Wang and Qinglang Li and William C. Parks},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Lung injury promotes the expression of matrix metalloproteinase-7 (MMP7, matrilysin), which is required for neutrophil recruitment and re-epithelialization. MMP7 governs the lung inflammatory response through the shedding of syndecan-1. Because inflammation and repair are related events, we evaluated the role of syndecan-1 shedding in lung re-epithelialization. METHODOLOGY/PRINCIPAL FINDING Epithelial injury induced syndecan-1 shedding from wild-type epithelium but not from Mmp7… CONTINUE READING