MMP19 Is Essential for T Cell Development and T Cell-Mediated Cutaneous Immune Responses

@article{Beck2008MMP19IE,
  title={MMP19 Is Essential for T Cell Development and T Cell-Mediated Cutaneous Immune Responses},
  author={Inken Maria Beck and Ren{\'e} R{\"u}ckert and Katja Brandt and Markus Sebastian Mueller and Thorsten Sadowski and Rena Brauer and Peter Schirmacher and Rolf Mentlein and Radislav Sedl{\'a}{\vc}ek},
  journal={PLoS ONE},
  year={2008},
  volume={3},
  pages={221 - 233}
}
Matrix metalloproteinase-19 (MMP19) affects cell proliferation, adhesion, and migration in vitro but its physiological role in vivo is poorly understood. To determine the function of MMP19, we generated mice deficient for MMP19 by disrupting the catalytic domain of mmp19 gene. Although MMP19-deficient mice do not show overt developmental and morphological abnormalities they display a distinct physiological phenotype. In a model of contact hypersensitivity (CHS) MMP19-deficient mice showed… CONTINUE READING

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