MMP12, lung function, and COPD in high-risk populations.

  title={MMP12, lung function, and COPD in high-risk populations.},
  author={Gary Matt Hunninghake and Michael H. Cho and Yohannes Tesfaigzi and Manuel E. Soto-Quiros and Lydiana Avila and Jessica A. Lasky-Su and Chris A Stidley and Erik Mel{\'e}n and Cilla S{\"o}derh{\"a}ll and Jenny Hallberg and Inger Kull and Juha Kere and Magnus Svartengren and G{\"o}ran Pershagen and Magnus Wickman and Christoph Lange and Dawn L. DeMeo and Craig P. Hersh and Barbara J. Klanderman and Benjamin A. Raby and David W Sparrow and Steven D Shapiro and Edwin K. Silverman and Augusto A Litonjua and Scott T. Weiss and Juan C Celed{\'o}n},
  journal={The New England journal of medicine},
  volume={361 27},
BACKGROUND Genetic variants influencing lung function in children and adults may ultimately lead to the development of chronic obstructive pulmonary disease (COPD), particularly in high-risk groups. METHODS We tested for an association between single-nucleotide polymorphisms (SNPs) in the gene encoding matrix metalloproteinase 12 (MMP12) and a measure of lung function (prebronchodilator forced expiratory volume in 1 second [FEV(1)]) in more than 8300 subjects in seven cohorts that included… CONTINUE READING


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