MMP-responsive theranostic nanoplatform based on mesoporous silica nanoparticles for tumor imaging and targeted drug delivery.

@article{Hu2016MMPresponsiveTN,
  title={MMP-responsive theranostic nanoplatform based on mesoporous silica nanoparticles for tumor imaging and targeted drug delivery.},
  author={Jing-Jing Hu and Li-Han Liu and Ze-yong Li and Ren-xi Zhuo and Xian‐Zheng Zhang},
  journal={Journal of materials chemistry. B},
  year={2016},
  volume={4 11},
  pages={
          1932-1940
        }
}
In this paper, we report on an intelligent mesoporous silica-based multifunctional theranostic nanoplatform (designated as MMTNP) for tumor imaging as well as controlled drug release. This theranostic nanoplatform consists of MCM-41 typical mesoporous silica nanoparticles (MSNs) as a hydrophobic drug carrier, matrix metalloprotease-2 (MMP-2) activated fluorescence imaging peptides on the surface of MSNs served as diagnostic probes as well as enzyme-responsive nanovalves blocking the pores, and… 
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