MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia.

@article{Yang2011MMPmediatedDO,
  title={MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia.},
  author={Yi Yang and Gary A Rosenberg},
  journal={Methods in molecular biology},
  year={2011},
  volume={762},
  pages={333-45}
}
The blood-brain barrier (BBB) has become a major focus of attention in cerebral pathophysiology and disease progression in the central nervous system. Endothelial tight junctions, the basal lamina, and perivascular astrocytes are jointly referred to as BBB or neurovascular unit. Around the cerebral endothelial cells is the basal lamina composed primarily of laminin, fibronectin, and heparan sulfate. The basal lamina provides a structural barrier to extravasation of cellular blood elements and… CONTINUE READING